Recent Advances in the Chemistry of Melanogenesis in Mammals
Journal of Investigative Dermatology (1980) 75, 122–127; doi:10.1111/1523-1747.ep12521344
Istituto di Chimica Organica e Biologica dell'Universita, Napoli, Italy
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The color of mammalian hair, skin, eyes results mainly from the secretory products of melanocytes. These secretory products consist of a wide range of melanin pigments with different structures compositions. These include black or brown nitrogenous eumelanins; yellow or reddish brown, sulfur-containing pheomelanins, e.g., the trichoomes of low molecular weight; other pigments whose chemical physical properties are intermediate between those of typical eumelanins pheomelanins. Despite the evident differences in molecular size general properties, all these pigments are biogenetically related, they arise from a common metabolic pathway in which dopaquinone is the key intermediate. The current state of knowledge on the molecular mechanisms governing the metabolic fate of dopaquinone in melanocytes is discussed with special reference to the role of such sulfhydryl compounds as cysteine glutathione in melanogenesis.
哺乳动物体内色素色素生化反应的研发进展
皮肤医科学刊，1980,75卷122-127页
意大利那波里戴尔大学，生化系
摘要
哺乳类动物、毛发、皮肤、眼睛内的色素都源自色素细胞产生的不同色素。色素有不同的结构及成份。包括黑色、棕色的含氮evmelanin色素及黄及红棕色的含硫的pheomelanins，并主宰了毛发中低原子量的色素。其他色素介于以上两者之间，所有色素从组成、结构来说都来自铬氨酸代谢出的中间产物dopaquinone,而dopanquinone在转变为各种不同色素过程中都会受到含有巯氧基的半胱氨酸及还原型谷胱甘肽阻断。